T23N (p.Thr23Asn) variant of CTLA4 (Cytotoxic T-lymphocyte protein 4)
T23N (p.Thr23Asn) in CTLA4 (Cytotoxic T-lymphocyte protein 4) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
T23N (p.Thr23Asn) variant details
- p.Thr23Asn
- TOPMed rs1365829864
- gnomAD rs1365829864
- Uncertain significance
- Missense
- Variant Prioritization Score for Impact Estimate 0.175
- MetaLR 0.06
- MetaSVM -1.05
- CADD 0.03
- PolyPhen-2 0.23
- SIFT 0.14
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available