P21H (p.Pro21His) variant of CTLA4 (Cytotoxic T-lymphocyte protein 4)
P21H (p.Pro21His) in CTLA4 (Cytotoxic T-lymphocyte protein 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data, published literature, and structural context.
P21H (p.Pro21His) variant details
- p.Pro21His
- gnomAD 2-203868004-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.285
- MetaLR 0.18
- MetaSVM -0.84
- CADD 16.80
- PolyPhen-2 0.68
- SIFT 0.11
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- Literature evidence available