L74I (p.Leu74Ile) variant of CTLA4 (Cytotoxic T-lymphocyte protein 4)
L74I (p.Leu74Ile) in CTLA4 (Cytotoxic T-lymphocyte protein 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data, published literature, and structural context.
L74I (p.Leu74Ile) variant details
- p.Leu74Ile
- gnomAD 2-203870696-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.369
- MetaLR 0.30
- MetaSVM -0.66
- CADD 22.30
- PolyPhen-2 0.50
- SIFT 0.03
- Population evidence available
- Structural context available
- Literature evidence available