L25P (p.Leu25Pro) variant of CTLA4 (Cytotoxic T-lymphocyte protein 4)
L25P (p.Leu25Pro) in CTLA4 (Cytotoxic T-lymphocyte protein 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.50 / 1. The record also includes population frequency data and structural context.
L25P (p.Leu25Pro) variant details
- p.Leu25Pro
- TOPMed rs1280951195
- gnomAD rs1280951195
- Missense
- Variant Prioritization Score for Impact Estimate 0.502
- MetaLR 0.14
- MetaSVM -0.96
- CADD 23.10
- PolyPhen-2 0.74
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available