L25L (p.Leu25Leu) variant of CTLA4 (Cytotoxic T-lymphocyte protein 4)
L25L (p.Leu25Leu) in CTLA4 (Cytotoxic T-lymphocyte protein 4) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data, published literature, and structural context.
L25L (p.Leu25Leu) variant details
- p.Leu25Leu
- rs16840275
- gnomAD 2-203868017-G-A
- Synonymous
- Variant Prioritization Score for Impact Estimate 0.362
- CADD 1.02
- Most common in the HGDP:LAHU population (allele frequency 0.1)
- Structural context available
- Cited in: Association study between polymorphisms of CD28, CTLA4 and ICOS and non-segmental vitiligo in a Korean population. (PMID 22977635)
- Cited in: Association of CTLA4 gene polymorphisms with susceptibility and pathology correlation to pulmonary tuberculosis in… (PMID 22811616)