F27L (p.Phe27Leu) variant of CTLA4 (Cytotoxic T-lymphocyte protein 4)
F27L (p.Phe27Leu) in CTLA4 (Cytotoxic T-lymphocyte protein 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
F27L (p.Phe27Leu) variant details
- p.Phe27Leu
- TOPMed rs1688660153
- Missense
- Variant Prioritization Score for Impact Estimate 0.232
- MetaLR 0.04
- MetaSVM -1.01
- CADD 14.50
- PolyPhen-2 0.00
- SIFT 0.34
- Most common in the Non-Finnish European population (allele frequency 5.4e-06)
- Structural context available