C3R (p.Cys3Arg) variant of CTLA4 (Cytotoxic T-lymphocyte protein 4)
C3R (p.Cys3Arg) in CTLA4 (Cytotoxic T-lymphocyte protein 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data, published literature, and structural context.
C3R (p.Cys3Arg) variant details
- p.Cys3Arg
- gnomAD 2-203867949-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.122
- MetaLR 0.04
- MetaSVM -1.02
- CADD 2.54
- PolyPhen-2 0.00
- SIFT 0.33
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available