Y59H (p.Tyr59His) variant of CRBN (Protein cereblon)
Y59H (p.Tyr59His) in CRBN (Protein cereblon) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.66 / 1. The record also includes population frequency data and structural context.
Y59H (p.Tyr59His) variant details
- p.Tyr59His
- gnomAD rs1308449938
- Missense
- Variant Prioritization Score for Impact Estimate 0.658
- REVEL 0.67
- CADD 26.50
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 0.00041)
- Structural context available