V110L (p.Val110Leu) variant of CRBN (Protein cereblon)
V110L (p.Val110Leu) in CRBN (Protein cereblon) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
V110L (p.Val110Leu) variant details
- p.Val110Leu
- TOPMed rs1460337269
- gnomAD rs1460337269
- Missense
- Variant Prioritization Score for Impact Estimate 0.337
- REVEL 0.12
- CADD 22.30
- PolyPhen-2 0.08
- SIFT 0.16
- Most common in the HGDP:BANTUSOUTHAFRICA population (allele frequency 0.19)
- Structural context available