R111W (p.Arg111Trp) variant of CRBN (Protein cereblon)
R111W (p.Arg111Trp) in CRBN (Protein cereblon) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.60 / 1. The record also includes population frequency data and structural context.
R111W (p.Arg111Trp) variant details
- p.Arg111Trp
- rs756895773
- NCI-TCGA Cosmic COSV9921
- cosmic curated COSV99214
- ExAC rs756895773
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.599
- REVEL 0.50
- CADD 33.00
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 5e-05)
- Structural context available