P22S (p.Pro22Ser) variant of CRBN (Protein cereblon)
P22S (p.Pro22Ser) in CRBN (Protein cereblon) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
P22S (p.Pro22Ser) variant details
- p.Pro22Ser
- TOPMed rs1303398008
- gnomAD rs1303398008
- Missense
- Variant Prioritization Score for Impact Estimate 0.253
- REVEL 0.06
- CADD 23.30
- PolyPhen-2 0.01
- SIFT 0.13
- Most common in the HGDP:PAPUANHIGHLANDS population (allele frequency 0.25)
- Structural context available