M89I (p.Met89Ile) variant of CRBN (Protein cereblon)
M89I (p.Met89Ile) in CRBN (Protein cereblon) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
M89I (p.Met89Ile) variant details
- p.Met89Ile
- rs760055652
- NCI-TCGA Cosmic COSV9921
- cosmic curated COSV99214
- ExAC rs760055652
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.33
- REVEL 0.05
- CADD 21.00
- PolyPhen-2 0.01
- SIFT 0.30
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Ashkenazi Jewish population (allele frequency 0.0037)
- Structural context available