M88T (p.Met88Thr) variant of CRBN (Protein cereblon)
M88T (p.Met88Thr) in CRBN (Protein cereblon) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data and structural context.
M88T (p.Met88Thr) variant details
- p.Met88Thr
- NCI-TCGA TCGA novel
- gnomAD rs1707736712
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.208
- REVEL 0.08
- CADD 16.40
- PolyPhen-2 0.00
- SIFT 0.60
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 0.00027)
- Structural context available