M109L (p.Met109Leu) variant of CRBN (Protein cereblon)
M109L (p.Met109Leu) in CRBN (Protein cereblon) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
M109L (p.Met109Leu) variant details
- p.Met109Leu
- TOPMed rs1707734095
- Missense
- Variant Prioritization Score for Impact Estimate 0.265
- REVEL 0.10
- CADD 22.40
- PolyPhen-2 0.05
- SIFT 0.13
- Most common in the HGDP:BIAKA population (allele frequency 0.091)
- Structural context available