G94R (p.Gly94Arg) variant of CRBN (Protein cereblon)
G94R (p.Gly94Arg) in CRBN (Protein cereblon) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.77 / 1. The record also includes population frequency data and structural context.
G94R (p.Gly94Arg) variant details
- p.Gly94Arg
- rs769962148
- NCI-TCGA Cosmic COSV5164
- cosmic curated COSV51640
- ExAC rs769962148
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.775
- REVEL 0.76
- CADD 27.50
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 0.00028)
- Structural context available