G61C (p.Gly61Cys) variant of CRBN (Protein cereblon)
G61C (p.Gly61Cys) in CRBN (Protein cereblon) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.70 / 1. The record also includes population frequency data and structural context.
G61C (p.Gly61Cys) variant details
- p.Gly61Cys
- Ensembl rs1559257423
- Missense
- Variant Prioritization Score for Impact Estimate 0.696
- REVEL 0.64
- CADD 24.80
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Ashkenazi Jewish population (allele frequency 0.0037)
- Structural context available