F67L (p.Phe67Leu) variant of CRBN (Protein cereblon)
F67L (p.Phe67Leu) in CRBN (Protein cereblon) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data and structural context.
F67L (p.Phe67Leu) variant details
- p.Phe67Leu
- ExAC rs777971005
- gnomAD rs777971005
- Missense
- Variant Prioritization Score for Impact Estimate 0.417
- REVEL 0.27
- CADD 23.40
- PolyPhen-2 0.58
- SIFT 0.62
- Most common in the HGDP:PAPUANHIGHLANDS population (allele frequency 0.25)
- Structural context available