D74N (p.Asp74Asn) variant of CRBN (Protein cereblon)
D74N (p.Asp74Asn) in CRBN (Protein cereblon) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data and structural context.
D74N (p.Asp74Asn) variant details
- p.Asp74Asn
- cosmic curated COSV10875
- gnomAD rs1480157421
- Missense
- Variant Prioritization Score for Impact Estimate 0.505
- REVEL 0.30
- CADD 25.70
- PolyPhen-2 0.99
- SIFT 0.01
- Most common in the HGDP:PALESTINIAN population (allele frequency 0.026)
- Structural context available