D63V (p.Asp63Val) variant of CRBN (Protein cereblon)
D63V (p.Asp63Val) in CRBN (Protein cereblon) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.61 / 1. The record also includes population frequency data and structural context.
D63V (p.Asp63Val) variant details
- p.Asp63Val
- TOPMed rs1222437889
- gnomAD rs1222437889
- Missense
- Variant Prioritization Score for Impact Estimate 0.606
- REVEL 0.59
- CADD 25.10
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 0.00027)
- Structural context available