D35E (p.Asp35Glu) variant of CRBN (Protein cereblon)
D35E (p.Asp35Glu) in CRBN (Protein cereblon) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
D35E (p.Asp35Glu) variant details
- p.Asp35Glu
- TOPMed rs1463720950
- gnomAD rs1463720950
- Missense
- Variant Prioritization Score for Impact Estimate 0.189
- REVEL 0.09
- CADD 20.20
- PolyPhen-2 0.01
- SIFT 0.25
- Most common in the African/African-American population (allele frequency 2.8e-05)
- Structural context available