D29G (p.Asp29Gly) variant of CRBN (Protein cereblon)
D29G (p.Asp29Gly) in CRBN (Protein cereblon) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data and structural context.
D29G (p.Asp29Gly) variant details
- p.Asp29Gly
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.283
- REVEL 0.15
- CADD 22.60
- PolyPhen-2 0.06
- SIFT 0.09
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 2.2e-05)
- Structural context available