p.Val20 Leu23del variant of COMT (Catechol O-methyltransferase)

Name: COMT p.Val20 Leu23del variant | CATVariant
Creator: Center for Precision Medicine and Data Sciences
Published: 2026-08-19
License: https://catvariant.com/terms-of-use

p.Val20 Leu23del in COMT (Catechol O-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data, published literature, and structural context.

p.Val20 Leu23del variant details

rs1942218448
gnomAD 22-19962572-CTGGT
Inframe Deletion
Variant Prioritization Score for Impact Estimate 0.26
CADD 16.00
Most common in the South Asian population (allele frequency 0.00021)
Structural context available
Literature evidence available