W38R (p.Trp38Arg) variant of COMT (Catechol O-methyltransferase)
W38R (p.Trp38Arg) in COMT (Catechol O-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data, published literature, and structural context.
W38R (p.Trp38Arg) variant details
- p.Trp38Arg
- gnomAD 22-19962638-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.509
- REVEL 0.46
- MetaLR 0.45
- MetaSVM -0.11
- CADD 25.30
- PolyPhen-2 0.94
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available