W31R (p.Trp31Arg) variant of COMT (Catechol O-methyltransferase)
W31R (p.Trp31Arg) in COMT (Catechol O-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data, published literature, and structural context.
W31R (p.Trp31Arg) variant details
- p.Trp31Arg
- gnomAD 22-19962617-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.197
- REVEL 0.19
- MetaLR 0.15
- MetaSVM -0.96
- CADD 14.80
- PolyPhen-2 0.20
- SIFT 0.18
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available