W29S (p.Trp29Ser) variant of COMT (Catechol O-methyltransferase)
W29S (p.Trp29Ser) in COMT (Catechol O-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data and structural context.
W29S (p.Trp29Ser) variant details
- p.Trp29Ser
- TOPMed rs1278178766
- Missense
- Variant Prioritization Score for Impact Estimate 0.11
- REVEL 0.09
- CADD 9.23
- PolyPhen-2 0.00
- SIFT 0.44
- Most common in the Middle Eastern population (allele frequency 0.00017)
- Structural context available