W29R (p.Trp29Arg) variant of COMT (Catechol O-methyltransferase)
W29R (p.Trp29Arg) in COMT (Catechol O-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data, published literature, and structural context.
W29R (p.Trp29Arg) variant details
- p.Trp29Arg
- gnomAD 22-19962611-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.124
- REVEL 0.11
- MetaLR 0.12
- MetaSVM -1.02
- CADD 3.38
- PolyPhen-2 0.00
- SIFT 0.46
- Most common in the Finnish in Finland (FIN) population (allele frequency 2e-05)
- Structural context available
- Literature evidence available