V21M (p.Val21Met) variant of COMT (Catechol O-methyltransferase)
V21M (p.Val21Met) in COMT (Catechol O-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data and structural context.
V21M (p.Val21Met) variant details
- p.Val21Met
- ExAC rs781461677
- TOPMed rs781461677
- gnomAD rs781461677
- Missense
- Variant Prioritization Score for Impact Estimate 0.142
- REVEL 0.05
- CADD 3.01
- PolyPhen-2 0.08
- SIFT 0.19
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available