V21L (p.Val21Leu) variant of COMT (Catechol O-methyltransferase)
V21L (p.Val21Leu) in COMT (Catechol O-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data and structural context.
V21L (p.Val21Leu) variant details
- p.Val21Leu
- ExAC rs781461677
- TOPMed rs781461677
- gnomAD rs781461677
- Missense
- Variant Prioritization Score for Impact Estimate 0.153
- REVEL 0.08
- CADD 0.26
- PolyPhen-2 0.00
- SIFT 0.78
- Most common in the REMAINING population (allele frequency 5.1e-05)
- Structural context available