V20M (p.Val20Met) variant of COMT (Catechol O-methyltransferase)
V20M (p.Val20Met) in COMT (Catechol O-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.09 / 1. The record also includes population frequency data and structural context.
V20M (p.Val20Met) variant details
- p.Val20Met
- TOPMed rs559479480
- gnomAD rs559479480
- Missense
- Variant Prioritization Score for Impact Estimate 0.0942
- REVEL 0.07
- CADD 10.90
- PolyPhen-2 0.01
- SIFT 0.04
- Most common in the Latino/Admixed American population (allele frequency 2.5e-05)
- Structural context available