V17M (p.Val17Met) variant of COMT (Catechol O-methyltransferase)
V17M (p.Val17Met) in COMT (Catechol O-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data, published literature, and structural context.
V17M (p.Val17Met) variant details
- p.Val17Met
- gnomAD 22-19962575-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.313
- REVEL 0.11
- MetaLR 0.19
- MetaSVM -0.90
- CADD 9.45
- PolyPhen-2 0.10
- SIFT 0.12
- Population evidence available
- Structural context available
- Literature evidence available