V12M (p.Val12Met) variant of COMT (Catechol O-methyltransferase)
V12M (p.Val12Met) in COMT (Catechol O-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
V12M (p.Val12Met) variant details
- p.Val12Met
- TOPMed rs1415216107
- Missense
- Variant Prioritization Score for Impact Estimate 0.205
- REVEL 0.32
- CADD 0.72
- PolyPhen-2 0.02
- SIFT 0.08
- Most common in the Non-Finnish European population (allele frequency 1.8e-05)
- Structural context available