R27W (p.Arg27Trp) variant of COMT (Catechol O-methyltransferase)
R27W (p.Arg27Trp) in COMT (Catechol O-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data, published literature, and structural context.
R27W (p.Arg27Trp) variant details
- p.Arg27Trp
- gnomAD 22-19962605-A-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.171
- REVEL 0.20
- MetaLR 0.19
- MetaSVM -0.92
- CADD 3.83
- PolyPhen-2 0.01
- SIFT 0.06
- Population evidence available
- Structural context available
- Literature evidence available