P2A (p.Pro2Ala) variant of COMT (Catechol O-methyltransferase)
P2A (p.Pro2Ala) in COMT (Catechol O-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data, published literature, and structural context.
P2A (p.Pro2Ala) variant details
- p.Pro2Ala
- gnomAD 22-19962530-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.182
- REVEL 0.03
- MetaLR 0.11
- MetaSVM -1.07
- CADD 14.90
- PolyPhen-2 0.00
- SIFT 0.33
- Population evidence available
- Structural context available
- Literature evidence available