L9F (p.Leu9Phe) variant of COMT (Catechol O-methyltransferase)
L9F (p.Leu9Phe) in COMT (Catechol O-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data, published literature, and structural context.
L9F (p.Leu9Phe) variant details
- p.Leu9Phe
- gnomAD 22-19962553-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.21
- REVEL 0.12
- MetaLR 0.31
- MetaSVM -0.67
- CADD 14.10
- PolyPhen-2 0.02
- SIFT 0.06
- Population evidence available
- Structural context available
- Literature evidence available