L33P (p.Leu33Pro) variant of COMT (Catechol O-methyltransferase)
L33P (p.Leu33Pro) in COMT (Catechol O-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
L33P (p.Leu33Pro) variant details
- p.Leu33Pro
- Ensembl rs1942220905
- Missense
- Variant Prioritization Score for Impact Estimate 0.41
- REVEL 0.41
- CADD 16.40
- PolyPhen-2 0.27
- SIFT 0.04
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available