L25P (p.Leu25Pro) variant of COMT (Catechol O-methyltransferase)
L25P (p.Leu25Pro) in COMT (Catechol O-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data, published literature, and structural context.
L25P (p.Leu25Pro) variant details
- p.Leu25Pro
- gnomAD 22-19962600-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.163
- REVEL 0.18
- MetaLR 0.24
- MetaSVM -1.02
- CADD 3.07
- PolyPhen-2 0.00
- SIFT 0.08
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- Literature evidence available