L25F (p.Leu25Phe) variant of COMT (Catechol O-methyltransferase)
L25F (p.Leu25Phe) in COMT (Catechol O-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data and structural context.
L25F (p.Leu25Phe) variant details
- p.Leu25Phe
- ExAC rs750490382
- TOPMed rs750490382
- gnomAD rs750490382
- Missense
- Variant Prioritization Score for Impact Estimate 0.121
- REVEL 0.11
- CADD 0.00
- PolyPhen-2 0.00
- SIFT 0.64
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available