L13F (p.Leu13Phe) variant of COMT (Catechol O-methyltransferase)
L13F (p.Leu13Phe) in COMT (Catechol O-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data and structural context.
L13F (p.Leu13Phe) variant details
- p.Leu13Phe
- ExAC rs764392202
- TOPMed rs764392202
- gnomAD rs764392202
- Missense
- Variant Prioritization Score for Impact Estimate 0.115
- REVEL 0.15
- CADD 0.03
- PolyPhen-2 0.00
- SIFT 0.72
- Most common in the African/African-American population (allele frequency 0.00034)
- Structural context available