I59T (p.Ile59Thr) variant of COMT (Catechol O-methyltransferase)
I59T (p.Ile59Thr) in COMT (Catechol O-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.59 / 1. The record also includes population frequency data and structural context.
I59T (p.Ile59Thr) variant details
- p.Ile59Thr
- gnomAD rs1466865313
- Missense
- Variant Prioritization Score for Impact Estimate 0.592
- REVEL 0.58
- CADD 24.10
- PolyPhen-2 0.22
- SIFT 0.03
- Most common in the Latino/Admixed American population (allele frequency 4.5e-05)
- Structural context available