I59M (p.Ile59Met) variant of COMT (Catechol O-methyltransferase)
I59M (p.Ile59Met) in COMT (Catechol O-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data, published literature, and structural context.
I59M (p.Ile59Met) variant details
- p.Ile59Met
- gnomAD 22-19962703-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.331
- REVEL 0.45
- MetaLR 0.26
- MetaSVM -0.72
- CADD 11.10
- PolyPhen-2 0.26
- SIFT 0.14
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- Literature evidence available