I36V (p.Ile36Val) variant of COMT (Catechol O-methyltransferase)
I36V (p.Ile36Val) in COMT (Catechol O-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data, published literature, and structural context.
I36V (p.Ile36Val) variant details
- p.Ile36Val
- gnomAD 22-19962632-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.163
- REVEL 0.17
- MetaLR 0.16
- MetaSVM -0.96
- CADD 4.91
- PolyPhen-2 0.15
- SIFT 0.12
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available