I36M (p.Ile36Met) variant of COMT (Catechol O-methyltransferase)
I36M (p.Ile36Met) in COMT (Catechol O-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data, published literature, and structural context.
I36M (p.Ile36Met) variant details
- p.Ile36Met
- gnomAD 22-19962634-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.168
- REVEL 0.14
- MetaLR 0.27
- MetaSVM -0.75
- CADD 8.95
- PolyPhen-2 0.79
- SIFT 0.06
- Most common in the Non-Finnish European population (allele frequency 4.5e-06)
- Structural context available
- Literature evidence available