G37L (p.Gly37Leu) variant of COMT (Catechol O-methyltransferase)
G37L (p.Gly37Leu) in COMT (Catechol O-methyltransferase) is a protein-truncating change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data, published literature, and structural context.
G37L (p.Gly37Leu) variant details
- p.Gly37Leu
- gnomAD 22-19962634-C-CTT
- Frameshift
- Variant Prioritization Score for Impact Estimate 0.155
- CADD 10.50
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available