G37D (p.Gly37Asp) variant of COMT (Catechol O-methyltransferase)
G37D (p.Gly37Asp) in COMT (Catechol O-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.13 / 1. The record also includes population frequency data, published literature, and structural context.
G37D (p.Gly37Asp) variant details
- p.Gly37Asp
- gnomAD 22-19962636-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.134
- REVEL 0.14
- MetaLR 0.15
- MetaSVM -0.93
- CADD 0.01
- PolyPhen-2 0.06
- SIFT 0.20
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available
- Literature evidence available