G32D (p.Gly32Asp) variant of COMT (Catechol O-methyltransferase)
G32D (p.Gly32Asp) in COMT (Catechol O-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
G32D (p.Gly32Asp) variant details
- p.Gly32Asp
- ExAC rs748066830
- TOPMed rs748066830
- gnomAD rs748066830
- Missense
- Variant Prioritization Score for Impact Estimate 0.204
- REVEL 0.22
- CADD 15.90
- PolyPhen-2 0.54
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available