G15C (p.Gly15Cys) variant of COMT (Catechol O-methyltransferase)
G15C (p.Gly15Cys) in COMT (Catechol O-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data, published literature, and structural context.
G15C (p.Gly15Cys) variant details
- p.Gly15Cys
- gnomAD 22-19962569-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.301
- REVEL 0.24
- MetaLR 0.22
- MetaSVM -0.77
- CADD 18.00
- PolyPhen-2 0.11
- SIFT 0.09
- Most common in the Latino/Admixed American population (allele frequency 2.6e-05)
- Structural context available
- Literature evidence available