G15A (p.Gly15Ala) variant of COMT (Catechol O-methyltransferase)
G15A (p.Gly15Ala) in COMT (Catechol O-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
G15A (p.Gly15Ala) variant details
- p.Gly15Ala
- TOPMed rs1942218305
- Missense
- Variant Prioritization Score for Impact Estimate 0.157
- REVEL 0.09
- CADD 10.50
- PolyPhen-2 0.08
- SIFT 1.00
- Most common in the Non-Finnish European population (allele frequency 4.6e-06)
- Structural context available