A4P (p.Ala4Pro) variant of COMT (Catechol O-methyltransferase)
A4P (p.Ala4Pro) in COMT (Catechol O-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data, published literature, and structural context.
A4P (p.Ala4Pro) variant details
- p.Ala4Pro
- gnomAD 22-19962536-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.15
- REVEL 0.07
- MetaLR 0.11
- MetaSVM -1.02
- CADD 10.30
- PolyPhen-2 0.00
- SIFT 0.09
- Population evidence available
- Structural context available
- Literature evidence available