T65S (p.Thr65Ser) variant of COMP (P49747)
T65S (p.Thr65Ser) in COMP (P49747) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
T65S (p.Thr65Ser) variant details
- p.Thr65Ser
- gnomAD rs1349031878
- Missense
- Variant Prioritization Score for Impact Estimate 0.321
- REVEL 0.06
- ESM-1b 1.00
- AlphaMissense 0.43
- CADD 23.80
- PolyPhen-2 0.39
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available