R86W (p.Arg86Trp) variant of COMP (P49747)
R86W (p.Arg86Trp) in COMP (P49747) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.55 / 1. The record also includes population frequency data and structural context.
R86W (p.Arg86Trp) variant details
- p.Arg86Trp
- TOPMed rs963661241
- Missense
- Variant Prioritization Score for Impact Estimate 0.55
- REVEL 0.52
- ESM-1b 1.00
- AlphaMissense 0.12
- CADD 26.10
- PolyPhen-2 0.68
- SIFT 0.02
- Most common in the African/African-American population (allele frequency 3.1e-05)
- Structural context available